Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis

This study focused on the association between plaque psoriasis and polymorp hisms of several inflammation genes. Included in the study were 142 Caucasi an (Czech) patients with plaque psoriasis and 141 healthy subjects. The gen otypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301) and in lymphotoxin alpha (TNF beta) (NcoI in intron 1) were detected by polymerase chain reaction-based methods and restriction enzyme analysis. An increase in B1 (less frequent) allele of NcoI TNF beta polymor phism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6, 95% confidence interval 1.13-2.26, P = 0.006), A. positive fa mily history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF beta (P = 0.011), Hardy-Weinberg disequilibrium was found in TA P1. polymorphism A-->G at nucleotide 1207 in psoriatic patients. A case-con trol difference was found in the allelic concurrence of M235T and A(-6)G AT G polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0. 29, 95% confidence interval 0.14-0.60, P = 0.0003), A positive history of t onsillitis and/or tonsillectomy was associated with a higher T allele frequ ency of the M235T ATG polymorphism (P = 0.037) as well as with a higher G a llele frequency of the A(-6)G ATG polymorphism (P = 0.022), Polymorphisms i n proinflammatory angiotensinogen and TNF beta genes were associated with p laque psoriasis, a positive family history of psoriasis and with frequent t onsillitis in childhood.