Pharmacokinetic variables of propofol were studied in 8 foals. Plasma level
s of propofol at different time after a single intravenous dose of 2.4 mg/k
g bw, were determined by HPLC. An open two compartments model was used to e
valuate plasma levels of propofol and values of t(1/2)alpha, t(1/2)beta Vd(
c), Vd(ss), Vd beta, Cl-total y MRT were obtained. Propofol pharmacokinetic
disposition showed a rapid distribution and removal from organic tissues,
and the reported pharmacokinetic variables contribute to determine the appr
opriate dose to be given.