Pharmacokinetics of propofol in 10 to 15 days old foals

Pharmacokinetic variables of propofol were studied in 8 foals. Plasma level s of propofol at different time after a single intravenous dose of 2.4 mg/k g bw, were determined by HPLC. An open two compartments model was used to e valuate plasma levels of propofol and values of t(1/2)alpha, t(1/2)beta Vd( c), Vd(ss), Vd beta, Cl-total y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appr opriate dose to be given.