Selenium altered the levels of lipids, lipid peroxidation, and sulfhydryl groups in straitum and thalamus of rat

The effect of sodium selenite (0.05, 0.1, and 0.2 mg/kg body weight, ip) on the lipid levels (total lipids, phospholipids, cholesterol, gangliosides), thiobarbituric acid reactive substance (TBARS), and sulfhydryl group (-SH) in the straitum and thalamus of a male Wistar rat was studied after 7 d of treatment. The level of total lipids and cholesterol was significantly and dose-dependently elevated in the straitum and thalamus with 0.1 and 0.2 mg /kg of sodium selenite. However, the cholesterol level was significantly in creased only with 0.2 mg/kg of sodium selenite in the thalamus. The level o f phospholipids and gangliosides was more significant with 0.1 mg/kg of sod ium selenite as compared to 0.2 mg. No significant alteration on the gangli osides level was observed in the thalamus with various doses of sodium sele nite although the elevation with 0.2 mg dose was 25.9%. The content of TBAR S was elevated dose dependently in straitum, but its level was depleted sig nificantly with 0.1-mg/kg dose of sodium selenite in the thalamus. The leve l of the -SH group was significantly depleted in the straitum with 0.1-mg/k g dose of sodium selenite; conversely, this dose has significantly elevated the levels of -SH group in the thalamus.