Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation

We report an 81-year-old female with a heterozygous factor V Leiden mutatio n who developed purpura fulminans. Digital necrosis, a characteristic clini cal feature of purpura fulminans was prominent. Purpura fulminans is more c ommon in children and adult, cases are rare. Of eight reported cases of pur pura fulminans resulting from a heterozygous factor V Leiden mutation recor ded in the literature, only two were in adults: 40 and 42 years of age, res pectively. This is the first report of this condition arising in a patient in her eighties.