Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebocontrolled trial

Objective To determine whether Ginkgo biloba is effective in treating tinni tus. Design Double blind, placebo controlled trial using postal questionnaires. Participants 1121 healthy people aged between 18 and 70 years with tinnitus that was comparatively stable; 978 participants were matched (489 pairs). Intervention 12 weeks' treatment with either 50 mg Ginkgo biloba extract LI 1370 three times daily or placebo. Main outcome measures Participants' assessment of tinnitus before, during, and after treatment Questionnaires included items assessing perception of h ow loud and how troublesome tinnitus was. Changes in loudness were rated on a six point scale. Changes in how troublesome were rated on a five point s cale. Results There were no significant differences in primary or secondary outco me measures between the groups. 34 of 360 participants receiving active tre atment reported that their tinnitus was less troublesome after 12 weeks of treatment compared with 35 of 360 participants who took placebo. Conclusions 50 mg Ginkgo biloba extract LI 1370 given 3 times daily for 12 weeks is no more effective than placebo in treating tinnitus.