HPLC determination of lorazepam and lorazepam-related compounds in pharmaceutical formulations

Authors
Orlovic, D Radulovic, D Ivanovic, D Vujic, Z
Citation
D. Orlovic et al., HPLC determination of lorazepam and lorazepam-related compounds in pharmaceutical formulations, CHROMATOGR, 52(11-12), 2000, pp. 732-734
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHROMATOGRAPHIA
ISSN journal
00095893 → ACNP
Volume
52
Issue
11-12
Year of publication
2000
Pages
732 - 734
Database
ISI
SICI code
0009-5893(200012)52:11-12<732:HDOLAL>2.0.ZU;2-D
Abstract
A sensitive, accurate and reproducible high performance liquid chromatograp hic (HPLC) procedure has been developed for the separation and analysis of lorazepam and related compounds. A 20-muL sample was separated by reversed- phase HPLC on a 150 mm x 4.6 mm, 5-mum particle, Wakosil column with 0.1 M ammonium acetate (pH adjusted to 6.0 with acetic acid)-acetonitrile-methano l, 1:1:1 (v/v) as mobile phase.