Microsatellite haplotypes associations with 5 CFTR mutations in >> Grande Briere <<, an isolate located in Southern Brittany

The variability at three microsatellites in the Cystic Fibrosis Transmembra ne Conductance Regulator Gene (CFTR) locus has been studied for frequent mu tations encountered in an isolated population of "Grande Briere" a small re gion located in Southern Brittany. Fluorescent multiplex PCR of these micro satellites were assayed in 16 Cystic Fibrosis (CF) families carrying 5 diff erent mutations. The four most frequent haplotypes on df508 chromosomes wer e the same as those found in Northern France and Europe but the distributio n of these haplotypes provides new enlightenment on the population origin o f this insular community.