HLA class I polymorphism in the Albanian population

The HLA class I polymorphism was studied in a sample of the Albanian popula tion. Ninety-three unrelated healthy Albanians were typed for HLA-A, -B and -Cw antigens by standard microlyphocytotoxicity test. The antigens with th e highest frequencies were: HLA-A2 (34.4%), A3 (14.5%) and AI (12.4%); B51 (19.3%), B35 (12.4%) and B18 (10.2%); Cw4 (16.2%), Cw7 (16.2%) and Cw6 (10. 8%). The HLA haplotypes with high frequency in Albanians included A2-B51 (4 .3%), A2-B18 (2.4%), A2-B35 (2.4%), Cw4-B35 (7.6%), and Cw7-B18 (6.5%), whi ch are not significantly different from the other neighboring populations. Low frequency of HLA-A1-B8 haplotype (1.1%) is noted in the Albanian popula tion. The frequency of HLA-B27 antigen (1.1%) is one of the lowest frequenc ies observed in Caucasians. Such results are important in studies of HLA-A1 -B8, HLA-B27 and disease associations. These findings should be also useful in understanding the origin of Albanians, representing a base for future s tudies about HLA polymorphism in the Albanian population.