NEW SYNTHESIS OF (METHOXYCARBONYL)-INDOLIZIDIN-7-ONE AND (METHOXYCARBONYL)-QUINOLIZIDIN-2-ONE - AN ACCESS TO BETA-AMINO ACIDS WITH INDOLIZIDINE AND QUINOLIZIDINE BACKBONE

Authors
CORDERO FM MACHETTI F DESARLO F BRANDI A
Citation
Fm. Cordero et al., NEW SYNTHESIS OF (METHOXYCARBONYL)-INDOLIZIDIN-7-ONE AND (METHOXYCARBONYL)-QUINOLIZIDIN-2-ONE - AN ACCESS TO BETA-AMINO ACIDS WITH INDOLIZIDINE AND QUINOLIZIDINE BACKBONE, Gazzetta chimica italiana, 127(1), 1997, pp. 25-29
Citations number
24
Categorie Soggetti
Chemistry
Journal title
Gazzetta chimica italiana → ACNP
ISSN journal
00165603
Volume
127
Issue
1
Year of publication
1997
Pages
25 - 29
Database
ISI
SICI code
0016-5603(1997)127:1<25:NSO(A(>2.0.ZU;2-7
Abstract
Two protected beta-amino acids containing the indolizidine or quinoliz idine skeleton have been synthesised. The key step of the strategy is represented by the new synthesis of indolizidinone and quinolizidinone II carried out by the opening of the tricyclic 1,3-dipolar cycloaddit ion products 17 or 18 with DABCO. A new and more convenient method for the synthesis of the cyclic hydroxylamines 13 and 14 precursors of ni trones is also reported.