Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics

A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested fo r anti-inflammatory and antimicrobial activities. The anti-inflammatory act ivities were determined in the rat paw oedema induced by carrageenin. Compo unds 6a, c, f and g (i.v.) significantly inhibited the rat paw oedema induc ed by carrageenin depending upon the dose employed. The compounds were also evaluated for their in vitro antimicrobial activity. Some compounds were f ound to have significant activity against Gram positive and Gram negative m icroorganisms. (C) 2000 Elsevier Science S.A. All rights reserved.