Structure-activity relationships for the analgesic activity of gallic acidderivatives

Authors
Krogh, R Yunes, RA Andricopulo, AD
Citation
R. Krogh et al., Structure-activity relationships for the analgesic activity of gallic acidderivatives, FARMACO, 55(11-12), 2000, pp. 730-735
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
55
Issue
11-12
Year of publication
2000
Pages
730 - 735
Database
ISI
SICI code
0014-827X(200011/12)55:11-12<730:SRFTAA>2.0.ZU;2-#
Abstract
Values of ID50 for a collection of structurally-related gallic acid derivat ives have been employed to create a predictive quantitative structure-activ ity relationship (QSAR) which links structure to values of analgesic activi ty. The QSAR model developed has substantial predictive power for the desig n of novel gallic acid derivatives having improved analgesic potency. (C) 2 000 Elsevier Science S.A. All rights reserved.