The question of the function of antioxidants in human health can only be re
solved when validated markers of oxidative damage are available. Markers al
low determination of the effect of antioxidants on damage to DNA, proteins,
and lipids. The final goal is the execution of human intervention studies
based on markers that are clearly linked to physiological function. These d
ata will be critical in determining the effectiveness of nutrients in promo
ting health and wellbeing and reducing disease risk.