B. De Bernardi et al., Neuroblastoma with symptomatic spinal cord compression at diagnosis: Treatment and results with 76 cases, J CL ONCOL, 19(1), 2001, pp. 183-190
Purpose: To report on the treatment of patients with newly diagnosed neurob
lastoma presenting with spinal cord compression (SCC).
Patients and Methods: Of 1,462 children with neuroblastoma registered betwe
en 1979 and 1998, 76 (5.2%) presented with signs/symptoms of SCC, including
motor deficit in 75 patients (mild in 43, moderate in 22, severe [ie, para
plegia] in 10), pain in 47, sphincteric deficit in 30, and sensory loss in
11. Treatment of SCC consisted of radiotherapy in 11 patients, laminectomy
in 32, and chemotherapy in 33. Laminectomy was more frequently performed in
eases with favorable disease stages and in those with severe motor deficit
, whereas chemotherapy was preferred in patients with advanced disease.
Results: Thirty-three patients achieved full neurologic recovery, 14 improv
ed, 22 remained stable, and eight worsened, including three who become para
plegic. None of the 10 patients with grade 3 motor deficit, eight of whom w
ere treated by laminectomy, recovered or improved. In the other 66 patients
, the neurologic response to treatment was comparable for the three therape
utic modalities. All 11 patients treated by radiotherapy and 26 of 32 patie
nts treated by laminectomy, but only two of 33 treated by chemotherapy, rec
eived additional therapy for SCC. Fifty-four of 76 patients are alive at ti
me of the analysis, with follow-up of 4 to 209 months (median, 139 months).
Twenty-six (44%) of 54 survivors have late sequelae, mainly scoliosis and
sphincteric deficit.
Conclusion: Radiotherapy, laminectomy, and chemotherapy showed comparable a
bility to relieve or improve SCC. However, patients treated with chemothera
py usually did not require additional therapy, whereas patients treated eit
her with radiotherapy or laminectomy commonly did. No patient presenting wi
th (or developing) severe motor deficit recovered or improved. Sequelae wer
e documented in 44% of surviving patients. J Clin Oncol 19:183-190. (C) 200
1 by American Society of Clinical Oncology.