Introduction: Although recent studies have demonstrated that the endpoint o
f isthmus conduction block is superior to that of termination and subsequen
t inability to induce atrial flutter (AFl), the optimal method for determin
ing isthmus conduction block has not been determined. Electroanatomic magne
tic mapping during coronary sinus (CS) pacing may provide a reliable endpoi
nt for AFl ablation.
Methods and Results: Catheter mapping and ablation was performed in 42 pati
ents with isthmus-dependent AFl. The patients were divided into two groups,
based on procedural endpoint: Group I (28 patients) - isthmus conduction b
lock was determined based on multipolar catheter recordings and electroanat
omic mapping, and Group II (14 patients) - isthmus conduction block was det
ermined by electroanatomic mapping during CS pacing alone. In Group I, abla
tion procedures were acutely successful in 25 of 28 patients (89 %). A 100
% concordance between the data presented by multipolar catheter recordings
and electroanatomic mapping was noted in determining the presence or absenc
e of isthmus conduction block. In Group II, ablation procedures were acutel
y successful in 13 of 14 patients, 13 (93 %). After a mean of 16.3 +/- 3.7
months follow up, there was 1 atrial flutter recurrence in the 38 patients
(2.6 %) with demonstrated isthmus block at the end of the procedure.
Conclusions: Electroanatomic magnetic mapping during CS pacing is comparabl
e to the multipolar catheter mapping technique for assessing isthmus conduc
tion block as an endpoint for AFl ablation procedures.