Homogeneity and diameter of linear lesions induced with multipolar ablation catheters: In vitro and in vivo comparison of pulsed versus continuous radiofrequency energy delivery

Background: For invasive treatment of atrial fibrillation, linear lesions i nduced with multipolar ablation catheters (MAC) are needed to prevent recur rence. The aim of the study was to compare the efficacy of pulsed versus co ntinuous radiofrequency (RF)-energy delivery using MAC. Methods: In vitro tests were performed using endomyocardial preparations of fresh pig hearts in a 10-liter-bath of physiologic saline solution (37 deg reesC) at constant flow conditions (1.5 l/min). The MAC were placed with a constant pressure of 20 ponds onto the endocardium. The energy (generator: Osypka HAT 200 S) was delivered either pulsed (4 electrodes simultaneously, 5 ms duty-cycle) or continuously (each electrode separately). In vivo expe riments were performed in 6 anesthetized pigs using fluoroscopic positionin g of MAC at 40 different intracardial positions and with similar conditions as in vitro experiments. Lesion volume (LV) was calculated after measuring lesion diameter with a microcaliper. The homogeneity of the lesions (LH) w as classified from 1-4; with 1 as highest homogeneity. Results: Pulsed energy delivery produced more homogeneous linear lesions in significantly less time. There was no difference in electrode temperature values (50.2 +/- 0.8 and 51.3 +/- 1.4 degreesC) in vitro and in vivo. In th e in vivo experiments, lesion depth and calculated lesion volume were less in both modes of energy delivery but pulsed energy delivery was superior re garding lesion depth and homogeneity. Conclusion: With pulsed energy delivery it is possible to create linear les ions of significantly greater homogeneity. Moreover, larger lesions are ind uced in less time by pulsed energy delivery in vitro and in vivo.