Preclinical and clinical evidence for efficient opsonization of poly(ethyleneglycol)-liposomes

Authors
Storm, G Laverman, P Dams, ETM Oussoren, C Corstens, FHM Oyen, WJG Boerman, OC
Citation
G. Storm et al., Preclinical and clinical evidence for efficient opsonization of poly(ethyleneglycol)-liposomes, J LIPOS RES, 10(4), 2000, pp. 461-466
Citations number
17
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF LIPOSOME RESEARCH
ISSN journal
08982104 → ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
461 - 466
Database
ISI
SICI code
0898-2104(2000)10:4<461:PACEFE>2.0.ZU;2-L
Abstract
The clinical use of poly(ethyleneglycol)-coated liposomes (PEG-liposomes) i s becoming increasingly important. Here we summarize our recent preclinical and clinical evidence pointing to the possibility of efficient opsonizatio n of intravenously injected PEG-liposomes under certain circumstances. Dras tically enhanced blood clearance of PEG-liposomes was observed at low lipid dose and in case of multiple injection schemes. Further clinical evaluatio n of the observed ''anti-stealth'' phenomenon is indicated.