we give a compact non-technical presentation of two basic principles for re
ducing the description of nonequilibrium systems based on the quasi-equilib
rium approximation. These two principles are: construction of invariant man
ifolds for the dissipative microscopic dynamics, and coarse-graining for th
e entropy-conserving microscopic dynamics. Two new results are presented: f
irst, an application of the invariance principle to hybridization of micro-
macro integration schemes is introduced, and is illustrated with non-linear
dumbbell models; second, Ehrenfest's coarse-graining is extended to genera
l quasi-equilibrium approximations, which gives the simplest way to derive
dissipative equations from the Liouville equation in the short memory appro
ximation (C) 2001 Elsevier Science B.V. All rights reserved.