Quantitative assessment of in vivo bone regeneration consolidation in distraction osteogenesis

Citation
H. Windhagen et al., Quantitative assessment of in vivo bone regeneration consolidation in distraction osteogenesis, J ORTHOP R, 18(6), 2000, pp. 912-919
Citations number
43
Categorie Soggetti
da verificare
Journal title
JOURNAL OF ORTHOPAEDIC RESEARCH
ISSN journal
07360266 → ACNP
Volume
18
Issue
6
Year of publication
2000
Pages
912 - 919
Database
ISI
SICI code
0736-0266(200011)18:6<912:QAOIVB>2.0.ZU;2-L
Abstract
We present a new method for quantitatively assessing the consolidation of b one regeneration by performing distraction osteogenesis in micropigs. We me asured in vivo stiffness using a newly developed, revolving, bone-healing m eter. After the micropigs were killed, we obtained maximum torsional moment data for the regenerated bones by destructive mechanical testing, and we t hen correlated these data with the data for stiffness. We found a highly si gnificant regression between in vivo stiffness and maximum torsional moment (r(2) = 0.80), suggesting that monitoring stiffness may be useful for the prediction of bone regeneration in distraction osteogenesis. Therefore, our method may be a reliable tool for future quantitative monitoring of healin g progress in patients with healing bones or in animal studies addressing t reatments to increase bone formation in long-bone defects.