This paper presents an overview of our research in robot-aided stroke neuro
-rehabilitation and recovery. At the onset of this research we had to confr
ont squarely (and solve!) a critical question: If anatomy is destiny, can w
e influence it? Our efforts over the last five years have been focused on a
nswering this question and we will present a few of our clinical results fr
om over 2,000 hours of robot-aided therapy with 76 stroke patients. To dete
rmine if exercise therapy influences plasticity and recovery of the brain f
ollowing a stroke, we needed the appropriate "microscope" that would allow
us to concomitantly control the amount of therapy delivered to a patient, w
hile objectively measuring patient's performance. Back-driveable robots are
the key enabling technology. Our results to date using common clinical sca
les suggest that robot-aided sensorimotor training does have a genuinely po
sitive effect on reduction of impairment and the reorganization of the adul
t brain. Yet while clinical scales can help us to examine the impact in the
neuro-recovery process, their coarse nature requires extensive and time-co
nsuming trials, and on top of that they fail to show us details important f
or optimizing therapy. Alternative, robot-based scales offer the potential
benefit of new finer measurements-and deeper insight into the process of re
covery from neurological injury. We also plan to use present technology to
establish the practicality and economic feasibility of clinician-supervised
, robot-administered therapy, including classroom therapy. We feel quite op
timistic that the march of progress will accelerate substantially in the ne
ar future and allow us to transfer this technology from the research realm
to the everyday treatment of stroke survivors.