For over 25 years, personal assistant robots for severely disabled individu
als have been in development. More recently, using robots to deliver rehabi
litation therapy has been proposed. This paper summarizes the development a
nd clinical testing of three mechatronic systems for post-stroke therapy co
nducted at the VA Pale Alto in collaboration with Stanford University. We d
escribe the philosophy and experiences that guided their evolution. Unique
to the Pale Alto approach is provision for bimanual, mirror-image, patient-
controlled therapeutic exercise. Proof-of-concept was established with 2-de
gree-of-freedom (DOF) elbow/forearm manipulator. Tests of a second-generati
on therapy robot producing planar forearm movements in 19 hemiplegic and co
ntrol subjects confirmed the validity and reliability of interaction forces
during mechanically assisted upper-limb movements. Clinical trials compari
ng 3-D robot-assisted therapy to traditional therapy in 21 chronic stroke s
ubjects showed significant improvement in the Fugl-Meyer (FM) measure of mo
tor recovery in the robot group, which exceeded improvements in the control
group.