The poxvirus family is a diverse and interesting group of viruses that affe
ct both humans and animals. Poxviruses are epitheliotropic and therefore ar
e of interest to the dermatologist. The genera of poxviruses known to affec
t humans are Orthopoxvirus, Parapoxvirus, Molluscipoxvirus. and Yatapoxviru
s. The different poxviruses are reviewed, including their history; incidenc
e, clinical presentation, and treatment.