Erythema nodosum in children: A prospective study

Background: The studies of series of children with erythema nodosum (EN) ar e limited and mostly retrospective. Objective: We evaluated the epidemiology; etiology, clinical manifestations , course, and prognosis of EN in children. Methods: Thirty-five children with EN (17 boys, 18 girls; mean age, 8.79) e ars) have been studied. Four excluded children proved, on biopsy: to have l eukocytoclastic vasculitis (n = 3) or eosinophilic cellulitis (n = 1) Results: In 27 of the 35 children (77%), the etiology of EN was established by laboratory investigations. In 25 children the causative factor of EN wa s an infectious agent (including beta -hemolytic streptococcus [n = 17], an d Mycobacterium tuberculosis [n = 2]), whereas in 2 patients, EN was associ ated with Crohn's disease in one and Hodgkin's disease in the other. In 8 o f the 35 children (23%) the etiology of EN remained undetermined. The mean duration of the rash was 11.5 days. Recurrences were noted in only 2 childr en (1 episode in 1 child and 3 episodes in the other). Conclusion: Currently the most common provoking agent of EN in children in Greece is beta -hemolytic streptococcus. However, Mycobacterium tuberculosi s should still be considered as a cause of the disorder. Also, the course o f EN is benign and recurrences are exceptional.