Inflammatory vitiligo in Vogt-Koyanagi-Harada disease

Vogt-Koyanagi-Harada disease is a rare disease characterized by uveitis, me ningitis, dysacusis, alopecia, poliosis, and vitiligo. We describe a 48-yea r old patient with Vogt-Koyanagi-Harada disease associated with thin inflam matory raised erythema and plaque-type inflammatory erythema superimposed o n vitiligo. Interestingly; inflammatory raised erythema was separated from the perfect vitiligo, and the incomplete vitiligo lay between them initiall y. Thereafter, incomplete vitiligo became completely depigmented with dimin ution of inflammatory raised erythema. This is the second case of vitiligo with inflammatory raised borders associated with Vogt-Koyanagi-Harada disea se. Our results of immunohistochemical anti electron microscopic studies su ggested the involvement of T-cell-mediated cytoxicity and apoptosis in the development of skin lesions.