No difference in cardiac event-free survival between positron emission tomography-guided and single-photon emission computed tomography-guided patient management - A prospective, randomized comparison of patients with suspicion of jeopardized myocardium
Hmj. Siebelink et al., No difference in cardiac event-free survival between positron emission tomography-guided and single-photon emission computed tomography-guided patient management - A prospective, randomized comparison of patients with suspicion of jeopardized myocardium, J AM COL C, 37(1), 2001, pp. 81-88
Citations number
41
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
OBJECTIVES We sought to prospectively compare nitrogen-13 (N-13)-ammonia/(1
8)fluorodeoxyglucose ((18)FDG) positron emission tomography (PET)-guided ma
nagement with stress/rest technetium-99m (Tc-99m)-sestamibi single-photon e
mission computed tomography (SPECT)-guided management
BACKGROUND Patients with evidence of jeopardized (i.e., ischemic or viable)
myocardium may benefit from revascularization, whereas patients without it
should be treated with drugs. Both PET and SPECT imaging have been proven
to delineate jeopardized myocardium. When patient management is based on id
entification of jeopardized myocardium, it is unknown which technique is mo
st accurate for long-term prognosis.
METHODS In a clinical setting, 103 patients considered for revascularizatio
n with left ventricular wall motion abnormalities and suspicion of jeopardi
zed myocardium underwent both PET and SPECT imaging. The imaging results we
re used in a randomized fashion to determine management (percutaneous trans
luminal coronary angioplasty [PTCA], coronary artery bypass graft surgery [
CABG] or drug treatment). Follow-up for cardiac events (cardiac death, myoc
ardial infarction and revascularization) was recorded for 28 +/- 1 months.
The study was designed to have a power of 80% to detect a 20% difference in
the event rate between PET and SPECT-based management.
RESULTS Management decisions in 49 patients randomized to PET (12 who had P
TCA, 14 CABG and 23 drug therapy) were comparable with 54 patients randomiz
ed to SPECT (15 who had PTCA, 13 CABG and 26 drug therapy). In terms of car
diac event-free survival, no differences between PET and SPECT were observe
d (11 vs. 13 cardiac events for PET and SPECT, respectively; p = NS by the
Kaplan-Meier statistic).
CONCLUSIONS No difference in patient management or cardiac event-free survi
val was demonstrated between management based on N-13-ammonia/(18)FDG PET a
nd that based on stress/rest Tc-99m-sestamibi SPECT imaging. Both technique
s may be used for management of patients considered for revascularization w
ith suspicion of jeopardized myocardium. (J Am Cell Cardiol 2001;37:81- 8)
(C) 2001 by the American College of Cardiology.