Ml. Ritchey et al., Surgical complications after primary nephrectomy for Wilms' tumor: Report from the National Wilms' Tumor Study Group, J AM COLL S, 192(1), 2001, pp. 63-68
BACKGROUND: Surgical complications are a recognized morbidity of the treatm
ent of patients with Wilms tumor. This study examines the incidence of surg
ical complications in the most recently completed study from the National W
ilms' Tumor Study Group (NWTSG).
STUDY DESIGN: The fourth National Wilms' Tumor Study (NWTS-4) enrolled 3,33
5 patients from August 1986 to August 1994. A random sample of 534 patients
was selected from 2,290 eligible patients randomized to treatment regimens
or enrolled in the followed category and treated according to NWTSG protoc
ol. The patient records received at the NWTSG Data and Statistical Center w
ere analyzed for surgical complications (intraoperative and postoperative).
RESULTS: Sixty-eight patients (12.7%) experienced 76 complications. Intesti
nal obstruction was the most common complication (5.1% of patients), follow
ed by extensive hemorrhage (1.9%), wound infection (2.9%), and vascular inj
ury (1.5%). The incidence of surgical complications in NWTS-4 was significa
ntly lower than NWTS-3 (12.7% versus 19.8%, p < 0.001). There has been a ma
rked decrease in the risk of extensive intraoperative bleeding and major in
traoperative complications. Factors previously shown to be associated with
an increased risk for surgical complications, together with indicators of t
ype of hospital and surgeon specialty, were analyzed by multiple logistic r
egression analysis. Intravascular extension into the inferior vena cava (IV
C), the atrium, or both (p = 0.02; odds ratio [OR] 3.8, 95% confidence inte
rval [CI] 1.2, 11.8), and nephrectomy performed through a flank or paramedi
an incision (p = 0.02; OR 5.3, 95% CI 1.3, 22) were both associated with in
creased risk of complications. Tumor diameter greater than or equal to 10 c
m was also associated with an increased risk of surgical complications (p =
0.05; OR 2.0, 95% CI 1.0, 3.9). The risk of complications was higher if th
e nephrectomy was performed by a general surgeon (OR 9.0, 95% CI 1.3, 65; p
= 0.03) rather than a pediatric surgeon (reference group, OR 1.0) or pedia
tric urologist (OR 0.7, 95% CI 0.3, 1.8).
CONCLUSIONS: The incidence of surgical complications in NWTSG patients unde
rgoing primary nephrectomy has significantly decreased over the past decade
. But surgical morbidity should not be overlooked. It is important that sur
geons treating young children with solid tumors are aware of their role and
the potential risks encountered in removal of the primary tumor. This stud
y found that surgical specialists who primarily treat children can perform
these operations with lower surgical morbidity. (J Am Coll Surg 2001;192:63
-68. (C) 2001 by the American College of Surgeons).