Synthesis of naturally occurring phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P-3] and its diastereoisomers

Authors
Gaffney, PRJ Reese, CB
Citation
Prj. Gaffney et Cb. Reese, Synthesis of naturally occurring phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P-3] and its diastereoisomers, J CHEM S P1, (2), 2001, pp. 192-205
Citations number
40
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
2
Year of publication
2001
Pages
192 - 205
Database
ISI
SICI code
1472-7781(2001):2<192:SONOP3>2.0.ZU;2-G
Abstract
The chemical synthesis of naturally occurring phosphatidylinositol 3,4,5-tr isphosphate [PtdIns(3,4,5)P-3] 2, in which the 1- and 2-hydroxy functions o f the glycerol moiety are esterified with stearic and arachidonic acid, res pectively, is described. The synthesis of three diastereoisomers 41, 42 and 43 of PtdIns(3,4,5)P-3 is also reported.