Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population

Apolipoprotein C-III (apoC-III) is the major component of triglyceride-rich lipoproteins. One of six identified polymorphisms in the apoC-III 5'-untra nslated region (T-455C) is located within a functional insulin-response ele ment. In a group of 137 elderly individuals (70-106 gears old), the allele distribution was analyzed using restriction fragment length polymorphisms. Statistical analysis of allele frequencies was performed on subgroups selec ted by age and in elderly patients with arterial hypertension or ischemic h eart disease. A greater frequency of the apoC-III -455C allele was demonstr ated with aging ( p.005). No statistically significant difference in allele distributions was detected between healthy subjects and groups of elderly patients of the same age with either ischemic heart disease or arterial hyp ertension. The increased incidence of the C allele with advanced age indica tes that this variant promoter is associated with longevity. The greater in cidence of this allele is detectable only in adults older than 80 years of age.