Medical abortion holds great promise in less-developed countries, where abo
rtion morbidity and mortality remain high. We tested the French mifepriston
e-misoprostol regimen in two urban outpatient family-planning clinics (n=60
0) and a rural hospital (n=300) in India. 4% of urban women and 1% of rural
women were lost to follow-up. Perfect use and typical-use success rates we
re as high as European rates at all sites. Although rural women reported fe
wer side-effects, most women in urban and rural settings were satisfied wit
h their medical abortions. Medical abortion can be offered safely, effectiv
ely, and acceptably in urban outpatient clinics and rural hospitals in Indi
a.