Fornix and hippocampal atrophy in traumatic brain injury

This study compared a fornix cross-sectional-area measurement and hippocamp al volume in 86 traumatic brain injury (TBI) subjects with 46 normal contro ls. The TBI group showed a significant reduction in fornix area and hippoca mpal volume. It was also shown that initial injury severity was related to the degree of atrophy in both structures. Although fornix size and hippocam pal volume correlated, such a modest correlation between these two structur es suggests differential and potentially independent mechanisms of injury. The General Memory Index score from the Wechsler Memory Scale-Revised was s hown to be significantly correlated with hippocampal volume following TBI.