N-aryl- or N-alkylpiperazine derivatives: The role of N-substituent on sigma(1), sigma(2), 5-HT1A and D-2 receptor affinity

Authors
Perrone, R Berardi, F Colabufo, NA Leopoldo, M Abate, C Tortorella, V
Citation
R. Perrone et al., N-aryl- or N-alkylpiperazine derivatives: The role of N-substituent on sigma(1), sigma(2), 5-HT1A and D-2 receptor affinity, MED CHEM RE, 10(4), 2000, pp. 201-207
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
MEDICINAL CHEMISTRY RESEARCH
ISSN journal
10542523 → ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
201 - 207
Database
ISI
SICI code
1054-2523(2000)10:4<201:NONDTR>2.0.ZU;2-7
Abstract
The binding profile at sigma (1), sigma (2), 5-HT1A and D-2 receptors of ei ght N-substituted-N'-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl ]piperazines is reported. Results indicated that a suitable substitution ca n lead to potent 5-HT1A or sigma (1), or sigma (2) ligands.