Hypothalamic GABA receptor functional regulation and liver cell proliferation

Authors
Biju, MP Pyroja, S Rajeshkumar, NV Paulose, CS
Citation
Mp. Biju et al., Hypothalamic GABA receptor functional regulation and liver cell proliferation, MOL C BIOCH, 216(1-2), 2001, pp. 65-70
Citations number
29
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN journal
03008177 → ACNP
Volume
216
Issue
1-2
Year of publication
2001
Pages
65 - 70
Database
ISI
SICI code
0300-8177(200101)216:1-2<65:HGRFRA>2.0.ZU;2-0
Abstract
GABAergic alterations in hypothalamus during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN) induced direct hyperplasia and N-nitrosodiethylamine (NDEA) induced neoplasia in liver were investigated. Serum GABA levels were increased in all 3 experimental groups compared wit h the control. GABA content decreased in hypothalamus of PH and NDEA treate d rats, while it increased in LN treated rats. GABA(A) receptor number and affinity in hypothalamic membrane preparations of rats showed a significant decrease in PH and NDEA treated rats, while in LN treated rats the affinit y increased without any change in the receptor number. The GABA(B) receptor number increased in PH and NDEA treated rats, while it decreased in LN tre ated rats. The affinity of the receptor also increased in NDEA treated rats . Plasma NE levels showed significant increase in PH and NDEA rats compared with the control while it decreased in LN treated rats. The results of the present study suggests that liver cell proliferation is influencing the hy pothalamic GABAergic neurotransmission and these changes regulate the hepat ic proliferation through the sympathetic stimulation.