5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency

Citation
Da. Franco et Hs. Greenberg, 5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency, NEUROLOGY, 56(1), 2001, pp. 110-112
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
56
Issue
1
Year of publication
2001
Pages
110 - 112
Database
ISI
SICI code
0028-3878(20010109)56:1<110:5MILAD>2.0.ZU;2-R
Abstract
Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinati ng syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU admi nistration not in association with levamisole. She was subsequently diagnos ed with partial deficiency of dihydropyrimidine dehydrogenase, an enzyme ne cessary for 5-FU catabolism. The authors suggest that MIL is a direct resul t of 5-FU chemotherapy and that patients with dihydropyrimidine dehydrogena se deficiency are at increased risk for this and other toxic effects of 5-F U.