Clinical and spectroscopic improvement in HIV-associated cognitive impairment

Authors
Stankoff, B Tourbah, A Suarez, S Turell, E Stievenart, JL Payan, C Coutellier, A Herson, S Baril, L Bricaire, F Calvez, V Cabanis, EA Lacomblez, L Lubetzki, C
Citation
B. Stankoff et al., Clinical and spectroscopic improvement in HIV-associated cognitive impairment, NEUROLOGY, 56(1), 2001, pp. 112-115
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
56
Issue
1
Year of publication
2001
Pages
112 - 115
Database
ISI
SICI code
0028-3878(20010109)56:1<112:CASIIH>2.0.ZU;2-X
Abstract
To assess the impact of highly active antiretroviral therapy (HAART) on AID S-associated cognitive impairment, 22 patients with AIDS with (n = 11) and without (n = 11) cognitive deficit were evaluated clinically and by MRS eve ry 3 months for 9 months. Nineteen patients were on HAART at study entry, 2 1 after 2 months. Cognitively impaired patients presented with a subcortico frontal deficit and decreased N-acetyl-aspartate in frontal white matter. T hese clinical and metabolic abnormalities reversed partially on HAART, wher eas they remained within normal limits in cognitively unimpaired patients.