Altered expression of synaptic proteins occurs early during progression ofAlzheimer's disease

Authors
Masliah, E Mallory, M Alford, M DeTeresa, R Hansen, LA McKeel, DW Morris, JC
Citation
E. Masliah et al., Altered expression of synaptic proteins occurs early during progression ofAlzheimer's disease, NEUROLOGY, 56(1), 2001, pp. 127-129
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
56
Issue
1
Year of publication
2001
Pages
127 - 129
Database
ISI
SICI code
0028-3878(20010109)56:1<127:AEOSPO>2.0.ZU;2-Z
Abstract
The expression levels of three synaptic proteins (synaptophysin, synaptotag min, and growth-associated protein 43 [GAP43]) in AD cases clinically class ified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to I) cases had a 25 % loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decr ement in these synaptic proteins. Thus, synaptic injury in frontal cortex i s an early event in AD.