Synthesis and antiviral evaluation of the beta-L-enantiomers of some thymine 3 '-deoxypentofuranonucleoside derivatives

3'-Deoxy-beta -L-erythro- (3), 3'-deoxy-beta -L-threo- (6), 2'-fluoro- (7) and 2'-azido-2',3'-dideoxy-beta -L-elythro- (10) pentofuranonucleoside deri vatives of thymine have been synthesized and their antiviral properties exa mined. All these derivatives were stereospecifically prepared by glycosylat ion of thymine with a suitable peracylated 3-deoxy-L-elythro-pentofuranose sugar (1), followed by appropriate chemical modifications. The prepared com pounds were tested for their activity against HIV, but they did not show an antiviral effect.