Obstetric implications of activated protein C resistance and factor V leiden Mutation

An increasing number of reports have focused on activated protein C resista nce (APCR) as it has been shown not only to be the most common genetic fact or predisposing patients to thromboembolic disease but the most common iden tifiable cause overall. More than 90 percent of the cases of APCR are cause d by the factor V Leiden mutation, in which a guanine to adenine substituti on in the factor V gene at nucleotide position 1691 results in a glutamine to arginine switch at position 506, Recent studies have also pointed to evi dence of an association between APOR/factor V Leiden mutation and hypertens ive disorders of pregnancy, first and second trimester miscarriage, placent al infarction, and placental abruption.