Oxytocin, plasma containing leukocytes or combination of both as treatmentof postbreeding endometritis in the horse

A total of 342 breeding cycles [262 lactating (L), 80 barren (B)] in 237 ma res were evaluated. The effect of the following variables on pregnancy (14 and 42 days) was analysed using a general linear model system. Each cycle w as randomly assigned to one of the following treatments: untreated control (T1); oxytocin (20 IU, i.v.), administered 0 and 12 to 16 h after breeding (T2); intrauterine infusion of leukocyte-enriched plasma (120 mi) 12 to 16 h after breeding (T3); combined treatment of oxytocin (20 IU, i.v.) adminis tered 0 h after breeding and leukocyte-enriched plasma infused 12-16 h afte r breeding/insemination The early pregnancy rate per cycle was significantl y higher (p < 0.05) in barren mares treated with plasma containing leukocyt es (78.6%) than in mares treated with oxytocin (50.0%) and in control mares (52.0%), but they did not differ from pregnancy rates obtained in mares tr eated with the combined treatment (69.2%, T4). The different treatments (T2 , T3, T4) did not affect significantly (p > 0.05) the pregnancy rate per cy cle in lactating mares when compared to control group. It was concluded tha t the infusion of leukocyte-enriched plasma improves pregnancy rate per cyc le in barren mares.