Effect of exercise on acid-base and blood gas changes in rats challenged with an inflammation agent

The aim of the study was to establish the effect of exercise stress upon th e acid-base and the blood gas status in rats with inflammation, provoked by the non-bacterial agent oyster glycogen. Rats with inflammation (controls) developed a decompensated metabolic acidosis that was the best manifested at posttreatment hour 72. The effect of stress on rats with inflammation (e xperimental group) was manifested with changes in both the dynamics and rat e of decompensated metabolic acidosis. It appeared earlier (hour 3) and was characterized by lower values of blood pH, bicarbonates - HCO3-, total car bon dioxide - TCO2, actual base excess - ABE, standard base excess - SBE, s tandard bicarbonate - SBC; indicative for impaired metabolic regulation. Th e values of partial pressures of carbon dioxide and oxygen (pCO(2), pO(2)), oxygen saturation - SAT and oxygen capacity - O2CT were also decreased, su ggesting changes in the respiratory system.