Insulators and long-distance interactions between regulatory elements in higher eukaryotes

Authors
Georgiev, PG Muravyova, EE Golovnin, AK Gracheva, EM Belenkaya, TY
Citation
Pg. Georgiev et al., Insulators and long-distance interactions between regulatory elements in higher eukaryotes, RUSS J GEN, 36(12), 2000, pp. 1336-1343
Citations number
37
Categorie Soggetti
Molecular Biology & Genetics
Journal title
RUSSIAN JOURNAL OF GENETICS
ISSN journal
10227954 → ACNP
Volume
36
Issue
12
Year of publication
2000
Pages
1336 - 1343
Database
ISI
SICI code
1022-7954(200012)36:12<1336:IALIBR>2.0.ZU;2-Y
Abstract
Enhancers can activate a promoter located as far as several hundred kilobas es away, which is specific for transcription regulation in higher eukaryote s. Notwithstanding the vast information accumulated on transcription regula tion at various levels, the mechanism of long-distance enhancer-promoter in teractions is still obscure. Modern views of insulators as elements modulat ing enhancer-promoter interactions are reviewed.