The malignant vascular tumors of bone represent an uncommon diverse group o
f tumors with widely variable clinical and radiographic presentations. Alth
ough the radiographic imaging features of the lytic osseous lesions typical
ly seen with this group of tumors are relatively nonspecific, the propensit
y to develop multifocal disease in an anatomic region is a feature that can
be helpful in suggesting the diagnosis of a vascular tumor. The differenti
al diagnosis varies according to the age of the patient and presence of sol
itary or multifocal disease. The histologic features are variable and range
from tumors with vasoformative features to those that mimic mesenchymal ne
oplasm or metastatic carcinoma. Familiarity with the radiographic and patho
logic spectrum of disease is essential for making an accurate diagnosis in
this diverse group of neoplasms. This paper will provide a review of the no
menclature for the malignant vascular tumors of bone and discuss the radiog
raphic and pathologic differential diagnosis.