A short and efficient synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid

Authors
Sturmer, R Schafer, B Wolfart, V Stahr, H Kazmaier, U Helmchen, G
Citation
R. Sturmer et al., A short and efficient synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid, SYNTHESIS-S, (1), 2001, pp. 46-48
Citations number
30
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
1
Year of publication
2001
Pages
46 - 48
Database
ISI
SICI code
0039-7881(200101):1<46:ASAESO>2.0.ZU;2-O
Abstract
A short and efficient synthesis of(S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carbox ylic acid is described. Starting from N-Boc-diallylamine, the synthesis inv olves ring-closing metathesis (RCM), directed alkoxycarbonylation (using st rong lithium bases and alkyl carbonates) and enzymatic kinetic resolution o f the racemate.