From dynamic to non-dynamic kinetic resolution of lactone-bridged biaryls:Synthesis of mastigophorene B

The atroposelective ring cleavage of configurationally unstable biaryl lact ones, by dynamic kinetic resolution, is an efficient tool for the stereosel ective synthesis of axially chiral biaryl target molecules. The recent exte nsion of this methodology to the kinetic resolution of configurationally st able biaryl lactones and its application to natural product synthesis is de scribed herein, exemplarily for the preparation of the nerve-growth stimula ting dimeric sesquiterpene mastigophorene B.