Virtual reality (VR) can be considered as the leading edge of a general evo
lution of present communication interfaces involving the television, comput
er, and telephone. The main characteristic of this evolution is the full im
mersion of the human sensorimotor channels into a vivid and global communic
ation experience. Because telemedicine principally focuses on transmitting
medical information, VR has the potential to enhance this function. Particu
larly, VR can be used in telemedicine as an advanced communication interfac
e, which enables a more intuitive mode of interacting with information, and
as a flexible environment that enhances the feeling of physical presence d
uring the interaction. In this article, the state of the art in VR-based te
lemedicine applications is described. This technology is now used in remote
or augmented surgery as well as surgical training, which are critically de
pendent on eye-hand coordination. Recently, however, different researchers
have tried to use virtual environments in medical visualization and for ass
essment and rehabilitation in neuropsychology. This article also discusses
technological, ergonomical, and human factor issues, and specific guideline
s are presented for expanding the use of VR in telemedicine.