Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants which
may cause cancer and require metabolic activation to exert their carcinogen
ic effects. As a step toward identifying the spectrum of PAH o-quinone-amin
o acid adducts that may form in biological systems, several naphthalene-1,2
-dione-amino acid adducts were synthesized. Each adduct was formed as a 1,4
-Michael addition product and spectral data corroborate that these adducts
were either o-quinones or catechols. PAH o-quinone adducts can be used as s
tandards to identify their presence in vitro and in vivo. (C) 2000 Elsevier
Science Ltd. All rights reserved.