MICROBIOLOGICAL TRANSFORMATIONS .37. AN ENANTIOCONVERGENT SYNTHESIS OF THE BETA-BLOCKER (R)-NIFENALOL(R) USING A COMBINED CHEMOENZYMATIC APPROACH

Authors
PEDRAGOSAMOREAU S MORISSEAU C BARATTI J ZYLBER J ARCHELAS A FURSTOSS R
Citation
S. Pedragosamoreau et al., MICROBIOLOGICAL TRANSFORMATIONS .37. AN ENANTIOCONVERGENT SYNTHESIS OF THE BETA-BLOCKER (R)-NIFENALOL(R) USING A COMBINED CHEMOENZYMATIC APPROACH, Tetrahedron, 53(28), 1997, pp. 9707-9714
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
28
Year of publication
1997
Pages
9707 - 9714
Database
ISI
SICI code
0040-4020(1997)53:28<9707:MT.AES>2.0.ZU;2-W
Abstract
This work describes the synthesis of (R)-Nifenalol(R) based on an enan tioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process . (C) 1997 Elsevier Science Ltd.