This manuscript represents the proceedings of a symposium at the 2000 RSA M
eeting in Denver, Colorado. The organizer/chair was Ting-Kai Li. The presen
tations were: (1) Introduction to the Symposium, by Ting-Kai Li; (2) ALDH2
polymorphism and alcohol metabolism, by Shih-Jiun Yin; (3) ALDH2 promoter p
olymorphism and alcohol metabolism, by David W. Crabb; (4) Use of BrAC clam
ping to estimate alcohol elimination rates: Application to studies of the i
nfluence of genetic and environmental determinants, by Sean O'Connor; and (
5) Effect of food and food composition on alcohol elimination rates as dete
rmined by clamping, by Vijay A. Ramchandani.