Effect of Dofetilide on the pharmacokinetics of digoxin

Authors
Kleinermans, D Nichols, DJ Dalrymple, I
Citation
D. Kleinermans et al., Effect of Dofetilide on the pharmacokinetics of digoxin, AM J CARD, 87(2), 2001, pp. 248
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
87
Issue
2
Year of publication
2001
Database
ISI
SICI code
0002-9149(20010115)87:2<248:EODOTP>2.0.ZU;2-Q
Abstract
The effect of dofetilide on the steady-state pharmacokinetics of digoxin wa s evaluated in a randomized, double-blind study, Five days of dofetilide tr eatment did not significantly affect steady-state pharmacokinetic variables of digoxin compared with placebo; therefore, the use of dofetilide does no t necessitate an adjustment in digoxin dose to maintain therapeutic digoxin levels.