Seroprevalence of Helicobacter pylori in patients with colorectal polyps and colorectal carcinoma

OBJECTIVES: The role of Helicobacter pylori in the pathogenesis of colorect al polyps and colorectal carcinoma is unknown. H. pylori infection causes f asting and meal stimulated hypergastrinemia. Gastrin increases colorectal m ucosal proliferation and promotes tumor growth. We performed a prospective study to determine the seroprevalence of H. pylori in patients with colorec tal polyps and colorectal carcinoma and in controls. METHODS: Blood samples were collected from 189 patients with colorectal car cinoma, 57 patients with colorectal polyps, and 179 controls. H. pylori ser ology was determined by an ELISA assay. RESULTS: Logistic regression showed no difference in seroprevalence of H. p ylori between patients with colorectal cancer and controls (odds ratio, 1.1 ; 95% confidence interval, 0.7 to 1.8) or between patients with colorectal polyps and controls (odds ratio 1.3; 95% confidence interval, 0.7 to 2.5). Age and sex were not found to be associated with H. pylori infection. Patie nts in social classes IV and V were 2.3 times more likely to have H. pylori infection than those in social classes I, II, and III (95% confidence inte rval, 1.3 to 4.2). CONCLUSIONS: This study shows that there is no increase in the seroprevalen ce of H. pylori in patients with colorectal polyps or colorectal carcinoma compared with controls. These results do not support the hypothesis that th ere is a relationship between H. pylori infection and the development of co lorectal neoplasia. (Am J Gastroenterol 2001;96: 84-88. (C) 2001 by Am. Col l. of Gastroenterology).