Response to measles, mumps, and rubella revaccination among HIV-positive and HIV-negative children and adolescents with hemophilia

The effect of human immunodeficiency virus (HIV) infection on response to m easles, mumps, and rubella revaccination in children and adolescents with h emophilia was evaluated. Antibody levels of measles, mumps, and rubella wer e assayed at baseline and two annual examinations in 207 HIV-positive and 1 26 HIV-negative hemophiliacs participating in the Hemophilia Growth and Dev elopment Study (HGDS). Response to revaccination was analyzed for participa nts whose antibody levels were below the cut off at the start of a year-lon g observation period. Among HIV-positive participants, antibody levels were below cut-off in 52 subjects for measles, in 71 for mumps, and in 96 for r ubella. Among HIV-negative participants, antibody levels were low in 23 sub jects for measles, in 23 for mumps, and in 31 for rubella. For measles and mumps antigens, revaccination was associated with a significant increase in redraw antibody levels for HIV-negative participants, Although there was a n increase in the mean measles titers for revaccinated HIV-positive partici pants, it was not significant. Revaccination was associated with an increas e in rubella antibodies in HIV-positive and HIV-negative participants. Reva ccination with measles and mumps was associated with an increase in antibod y levels in HIV-negative participants but not in HIV-positive participants, Both HIV-positive and HIV-negative participants responded to rubella revac cination with an increase in antibody levels. (C) 2001 Wiley-Liss, Inc.