Microspaeropsis olivacea keratitis and consecutive endophthalmitis

PURPOSE: To report a case of fungal keratitis with consecutive endophthalmi tis caused by Microshaeropsis olivacea, METHODS: Case report. RESULTS: A 51-year-old man developed fungal keratitis and consecutive endop hthalmitis after sustaining a penetrating injury to the right eye. Cultures of the aqueous humor yielded M. olivacea. Infection reserved after intraoc ular fungal debridement, intravitreous amphotericin B, and aggressive topic al natamycin and oral fluconatole, Persistent, low-grade smoldering corneal and intraocular inflammation required topical corticosteroid therapy. CONCLUSION: M. olivacea is an exceedingly rare ocular pathogen. The intraoc ular portion of the infection responded quickly to intravitreal antifungal treatment; however, the course was prolonged by smoldering corneal inflamma tion. Prompt recognition of intraocular spread and aggressive treatment. ma y be beneficial in fungal infections caused by unusual organisms with uncer tain virulence, (Am J Ophthalmol 2001;131:142-143. (C) 2001. by Elsevier Sc ience Inc. All rights reserved.).